Senior Scientist - Heme/Onc - Translational IPS

Company: Disability Solutions
Location: Cambridge
Posted on: November 3, 2024

Job Description:

Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: .When you join BMS, you are joining a diverse, high-achieving team united by a common mission. The Informatics and Predictive Sciences (IPS) mission is to Pioneer, Partner and Predict to drive transformative insights for patient benefit. IPS conducts applied computational research in areas that include genomic, structural and molecular informatics, computational and systems biology, patient selection and translational biomarker research, and broader fields including knowledge science, epidemiology and machine learning-across the full lifecycle of drug discovery and development and across all therapeutic areas at BMS. We do this in close partnership with scientific and clinical experts in the field, both inside and outside the company." We perform innovative science to empower key data-driven decisions across a rich pipeline of next-generation medicines. In doing so, our work transforms the lives of patients, as well as our own lives and careers.Here, you'll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You'll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.We seek a talented, collaborative inter-disciplinary computational scientist to work on the analysis, statistical modeling and generation of hypotheses from high-dimensional molecular profiling data. This individual will play a key scientific role leveraging innovative computational analysis strategies and rich patient data to empower data-driven decisions alongside BMS colleagues in our Informatics & Predictive Sciences department and in collaboration with internal partners in drug discovery and translational medicine research teams. Analysis scenarios will involve applying cutting-edge bioinformatics, statistics, and machine learning/AI methods; working with clinical and large-scale omics data and biomarker data sets that could include WGS/WES, RNA-Seq, scRNA-Seq, IHC, Spatial Transcriptomics, etc; from BMS's industrial-leading late-stage oncology clinical studies; influencing development strategies and advancing BMS hematology/oncology pipeline. This position offers the exciting opportunity to make major contributions to scientific knowledge of cancer disease biology, and to directly impact treatment of cancer patients. The position would suit an individual with strong computational capabilities, experience in hematology/oncology bioinfotrmatics and excellent communication and collaboration skills. Applications are encouraged from those involved in innovative translational research for hematology and/or solid tumor indications in clinical or industrial research environments. The role offers the opportunity to impact directly the delivery of truly transformational and life-changing therapies in key diseases of unmet medical need. Responsibilities

• Apply computational methods to molecular profiling datasets and develop hypotheses to stratify patients and prioritize indications, guiding clinical oncology development and reverse translation.
• Perform analysis of clinical and biomarker datasets (e.g., large-scale -omics datasets including RNASeq, and Whole Exome/Genome Sequencing) and derive clinically meaningful interpretations.
• Identify potential biomarkers for patient enrichment strategies and gain mechanistic insights of responses and resistances to treatments of interest.
• Drive in-depth analysis of stratified patient data to elucidate biological and driver mechanisms in key oncology indications (integrating multiple omics datasets, including scRNAseq).
• Work with colleagues in the Informatics & Predictive Sciences group to identify drivers of disease heterogeneity and potential therapeutic targets for patients in unmet need.
• Collaborate with experimental teams in the iterative validation of therapeutic and mechanistic therapeutic hypotheses.
• Summarize analysis results and report conclusions to BMS decision-making bodies. Basic Qualifications:
  • Bachelor's Degree 7+ years of academic / industry experience
  • Or Master's Degree 5+ years of academic / industry experience
  • Or PhD 2+ years of academic / industry experiencePreferred Qualifications:
    • Ph.D. or M.S. with 2+ years of experience in computational biology, bioinformatics, statistics or related fields. Experience in biotech or pharmaceutical industries is a plus.
    • Strong experience in the use of a high-level programming language such as R, MATLAB, Python or Perl for complex data analysis and reproducible research practices is a must.
    • Substantial experience working with Next Generation Sequencing datasets, including RNAseq, scRNAseq, Whole-Genome, Whole-Exome Sequencing and ChipSeq.
    • Familiarity with contemporary cloud and high-performance computing environments.
    • Expertise in application of contemporary machine-learning/AI approaches.
    • Ability to work both independently and collaboratively, and to handle several concurrent, fast-paced projects while conforming with rigorous requirements of clinical studies.
    • Strong problem-solving and collaboration skills, rigorous and creative thinking.
    • Excellent communication, data presentation, and visualization skills.
    • Fluent written and verbal English language communication. The starting compensation for this job is a range from $109,000 - 150,700, plus incentive cash and stock opportunities (based on eligibility). The starting pay takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation is decided based on demonstrated experience. For more on benefits, please visit our BMS Careers site. Eligibility for specific benefits listed in our careers site may vary based on the job and location.Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program. If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as Transforming patients' lives through science--- , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.On-site Protocol BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to . Visit to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Disability Solutions, Westfield , Senior Scientist - Heme/Onc - Translational IPS, Other , Cambridge, Massachusetts